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Clinical Research

 

Advancing the Field of Eyecare, One Clinical Study at a Time.

 

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Research at Cincinnati Eye Institute

Cincinnati Eye Institute is home to one of the largest and most prestigious private-sector clinical research departments in ophthalmology in the United States. The eye doctors and research staff at CEI have been conducting clinical research for more than 35 years and have participated in over 300 research studies. Our goal is to pave the way for tomorrow’s eye care and bring it to our patients today.

Cincinnati Eye Institute is always participating in numerous studies across various sub-specialties for adults. Most commonly our clinical research studies are for dry eyes, glaucoma, cataracts, macular degeneration, diabetes, and more. If you have questions about any of our current studies with open enrollment, please contact the Clinical Research department by calling 513-569-3688 or by completing the form below.

Current Clinical Studies

Glaucoma View

Glaukos (GLK-401-01)

Glaucoma surgical device study of the iStent Infinite
A Prospective, Multicenter Study of the Glaukos iStent Infinite Trabecular Micro-Bypass System Model IS3 in Subjects with Mild to Moderate Primary Open-Angle Glaucoma

  • Physician: Anup Khatana, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Lee Stokes, (513) 569-3213

Ivantis (CP 18-001)

Glaucoma surgical device post market study of the Hydrus microstent with cataract surgery
The Hydrus Microstent New Enrollment Post-Approval Study: A Prospective, Non-randomized, Multicenter, Single Arm, Clinical Trial (CONFIRM)

  • Physician: Edward Meier, MD
  • Location: 6150 Radio Way, Mason, OH 45040
  • Coordinator: Tina Winward, (513) 770-4020 ext.3324

iStar Medical (Star-V)

Glaucoma surgical device study of the MINIject CS627
A Prospective, Multicenter Masked Clinical Trial to Evaluate the Safety and Effectiveness of the MINIject CS627 Implant in Subjects with Open Angle Glaucoma

  • Physician: Edward Meier, MD
  • Location: 6150 Radio Way, Mason, OH 45040
  • Coordinator: Tina Winward, (513) 770-4020 ext.3324

 

Cataract Surgery & Intraocular Lens (IOL) Studies View

Alcon Research (ILQ137-C002)

Contralateral Study of Clareon PanOptix Pro vs. Clareon PanOptix

  • Physician: Michael Snyder, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Grace Bruns, (513) 569-3549

Cornea Studies View

Aurion Biotech (ABA-1)

Intracameral injection for certain corneal dystrophies
A Phase 1/2 Multi-Center, Randomized, Double-Masked, Prospective, Parallel-Arm Study of AURN001 in Subjects with Corneal Edema Secondary to Corneal Endothelial Dysfunction (CLARA)

  • Physician: Michael Nordlund, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Lee Stokes (513) 569-3213

Epion Therapeutics (CXL-006-A)

Corneal Treatment for Keratoconus
A Multicenter, Randomized, Double-Masked, Sham-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-On Corneal Cross-Linking in Subjects 8 to 45 Years of Age with Keratoconus

  • Physician: Adam Kaufman, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Meagana Wilkins, (513) 569-3285

Kowa Research (K-321-303)

Eye Drop Study for Corneal Treatment of Fuch’s Dystrophy after Cataract Surgery
A Double-Masked, Randomized, Placebo-Controlled, Parallel-Group, 12-Week Administration with Two-Week Gradual Dose Taper Phase and 38-Week Follow-Up Phase, Phase 3 Study to Investigate the Efficacy and Safety of Ripasudil (K-321) Eye Drops after Simultaneous Cataract Surgery and Descemetorhexis in Subjects with Fuchs Endothelial Corneal Dystrophy

  • Physician: Michael Nordlund, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Melissa Schoonover, (513) 569-3660

Dry Eye Disease View

Not Currently Enrolling

Retina View

RegenxBio-Ascent/Atmosphere (RGX-314-3101/2104)

Gene Therapy surgical trial for Wet AMD
A Randomized, partially Masked, Controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with AMD.

  • Physician: Robert Sisk, MD
  • Location: 9997 Carver Road, Cincinnati, OH 45242
  • Coordinator: Noah Wendt, (513) 569-3479

Opregen (GR44251)

Gene Therapy Surgical trial for dry AMD
A Phase IIa, Open-Label, Single-Arm, Multicenter Study to Optimize Subretinal Surgical Delivery of Opregen in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration

  • Physician: Christopher Riemann, MD
  • Location: 9997 Carver Road, Cincinnati, OH 45242
  • Coordinator: Ryanne Sullivan, (513) 569-3170

Genentech (ML43000 Belvedere)

Surgical trial for wet AMD using the port delivery system
A Phase IIIb/IV, Multicenter, Visual Assessor Masked Study of the Efficacy and Safety of the Port Delivery System with Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration Previously Treated with Intravitreal Agents Other than Ranibizumab.

  • Physician: Lucas Lindsell, OD, MD
  • Location: 9997 Carver Road, Cincinnati, OH 45242
  • Coordinator: Emily Collier, (513) 569-3178

Janssen (81201887MDG2001)

Injection trial for dry AMD 
A Phase 2/3, Randomized, Double-Masked, Multicenter, Dose-Ranging, Sham-Controlled Clinical Trial to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age Related Macular Degeneration (AMD) (PARASOL)

  • Physician: Lucas Lindsell, OD, MD
  • Location: 9997 Carver Road, Cincinnati, OH 45242
  • Coordinator: Ryanne Sullivan, (513) 569-3170

Beacon Therapeutics (RPGR-001 Dawn)

Gene Therapy Surgical Trial for x-linked Retinitis Pigmentosa
A Phase 1/2 Open-Label Dose Escalation Study to Evaluate the Safety and Efficacy of AGTC-501 (rAAV2tYF-GRK1-RPGR) and a Phase 2 Randomized, Controlled, Masked, Multi-Center Study Comparing Two Doses of AGTC-501 in Male Participants with X-Linked Retinitis Pigmentosa

  • Physician: Robert Sisk, MD
  • Location: 9997 Carver Road, Cincinnati, OH 45242
  • Coordinator: Noah Wendt, (513) 569-3479

Beacon Therapeutics (RPGR-002 Vista)

Gene Therapy Surgical Trial for x-linked Retinitis Pigmentosa
A Phase 2/3 Randomized, Controlled, Masked, Multi-Center Study to Evaluate the Efficacy, Safety and Tolerability of Two Doses of AGTC-501, a Recombinant Adeno-associated Virus Vector Expressing RPGR (rAAV2tYF-GRK1-RPGR), compared to an Untreated Control Group in Male Subjects with X-Linked Retinitis Pigmentosa Confirmed by a Pathogenic Variant in the RPGR Gene

  • Physician: Robert Sisk, MD
  • Location: 9997 Carver Road, Cincinnati, OH 45242
  • Coordinator: Noah Wendt, (513) 569-3479

Ascidian (ACDN-01-001)

Gene Therapy Surgical Trial for Stargardt’s Dystrophy
Open-Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Subretinally Delivered ACDN-01 in Participants with ABCA4-related Retinopathy (Stargardt’s/Rod-Cone Dystrophy)

  • Physician: Robert Sisk, MD
  • Location: 9997 Carver Road, Cincinnati, OH 45242
  • Coordinator: Ryanne Sullivan, (513) 569-3170

Meet Our Clinical Research Team

Megan Kingdon

Megan Kingdon, RN, BSN, CCRC, COA

Director of Clinical Research – EyeCare Partners

Kelye Conrad

Kelye Conrad, CCRC, COT, CPT

Clinical Research Manager, Ohio Region – EyeCare Partners

How Does Clinical Research Help Our Patients?

Thousands of patients with eye problems come to CEI each week to find leading-edge solutions to their eye care needs. In addition to patients from Ohio, Indiana, and Northern Kentucky, we see patients who travel from all over the nation to see our eye care experts. Our participation in clinical research allows us to offer patients the most advanced treatment options possible.

Staying on the Leading Edge of Eye Care Research

Our on-going commitment to physician-controlled eye care research enables us:

Contact Cincinnati Eye Institute

Do you have questions about ongoing clinical research at Cincinnati Eye Institute? Complete the form below to join our research registry, and a member of our team will contact you to discuss any questions you may have about active clinical trials.

Research Registry

The doctors at Cincinnati Eye Institute have either authored or reviewed the content on this site.

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